Progressive Morphological and Functional Defects in Retinas from α1 Integrin-Null Mice
نویسندگان
چکیده
METHODS. Immunolocalization and Western blot analysis of retinas and ARPE19 cells were performed to examine the expression of 1 1 integrin in the RPE. Retinal abnormality was assessed by funduscopy, histology, and transmission electron microscopy. Progressive retinal damage was quantified by direct counting of rod photoreceptors. Light-induced translocation of arrestin and -transducin was documented by immunohistochemical analysis of retinal cryosections.
منابع مشابه
Progressive morphological and functional defects in retinas from alpha1 integrin-null mice.
PURPOSE The role of integrin/cell matrix interactions between the RPE and the basement membrane in retinal maintenance and function is not well characterized. In this study the functional importance of alpha1beta1 integrin for retinal pigment epithelial cell homeostasis and retinal health was assessed by comparing alpha1 integrin knockout mice with strain- and age-matched wild-type mice. METH...
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